Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation
نویسندگان
چکیده
منابع مشابه
Waldenstrom’s Macroglobulinemia treated with fractionated low-dose total body irradiation
Case Report: A 78-year-old male with relapsed Waldenstrom’s macroglobulinemia following therapy with chlorambucil underwent a five-week course of TBI. The total dose delivered was 1.5 Gy, given as 0.15 Gy twice weekly for ten sessions. During the course of therapy his CD4 cells increased from 637 (cells/mm3) to 808 partly through treatment and then declined to 654 at the completion of therapy. ...
متن کامل[Antitumor effects by low dose total body irradiation].
Total-body irradiation (TBI) with 0.02-0.25 Gy has been reported to have antitumor effects. In mice, low-dose TBI induces tumor growth delay, antimetastatic effects, suppressive effects on the incidence of spontaneous thymiclymphoma, sensitization of tumor to ionizing radiation, and decrease in TD50 value. In artificial metastasis, 0.20 Gy TBI suppressed lung metastasis when it was conducted be...
متن کاملEndocrine deficit after fractionated total body irradiation.
Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid d...
متن کاملRadiation Sensitization of Leukemic Cells for Low Dose Total Body Irradiation
The treatment of pediatric leukemias has been developed through sequential clinical trials designed to improve patient survival and preserve quality of life (Brochstein et al., 1987). A patient's clinical and biological features are predictive of risk of relapse and determine the aggressiveness of the prescribed clinical treatment protocol. Patients determined to be at high risk for recurrence ...
متن کاملDiode calibration for dose determination in total body irradiation
Background: Total Body Irradiation (TBI) is different from standard radiotherapy in many aspects, so it is not easy to predict the delivered dose to the patient under TBI treatment. Diode dosimetry procedures for surface dose reading can help to define variations of the actually delivered dose from the prescribed one. The aim of this study was to describe the measurements made to calib...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.00317